英文名称

ActivAb^TMAnti-EMR1 Polyclonal Antibody

中文名称

ActivAb^TM粘附G蛋白偶联受体E1抗体

规格

100ul ; 50ul

宿主

Rabbit

克隆类型

Polyclonal Antibody

亚型

IgG

交叉反应

Mouse ; Human

应用

ELISA ; IF ; IHC ; WB

稀释比例

WB 1:500-2000. IHC 1:400-1600. IF 1:50-500.

靶标

EMR1

别名

ADGRE1, Adhesion G protein-coupled receptor E1, EGF like module receptor 1, EMR1, EMR1 hormone receptor, F4/80, TM7LN3

背景说明

EMR1 (EGF-like module containing mucin-like hormone receptor 1), also known as Adhesion G protein-coupled receptor E1 (ADGRE1), is a surface receptor with seven transmembrane segments that belongs to the EGF-7-transmembrane family of G protein-coupled receptors (PMID: 14647991, 7601460). EMR1 expression is restricted to eosinophilic granulocytes, where expression is overlapping with the eotaxin receptor CCR3 and the immunoglobulin-like lectin Siglec-8. Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans and may be used as a novel therapeutic target for eosinophilic disorders(PMID: 17823986, 24530099). F4/80, the murine homolog of EMR1, is a marker of murine macrophage. The apparent molecular weigh of F4/80 is 160 kDa, which is lager than the calculated molecular weight due to post-translational modifications (PMID: 7308288; 8647179).

Swiss Prot

Q14246

Gene ID

2015

亚细胞定位

Cell membrane Multi-pass membrane protein

免疫原

Recombinant protein of human EMR1

Public Immunogen Range

430-510aa

理论分子量

90kDa

纯化方法

Affinity purification

储存液

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

储存条件

Store at -20℃. Avoid freeze / thaw cycles.